尼克（艾伦•艾克哈特 Aaron Eckhart 饰）是这个世界上最赚钱也最富有争议的行业――烟草业 的代言人。他每天不仅要像推销员一样用三寸不烂之舌去说服人们抽烟，还要不得不变着法子去对付禁烟团体、环保团体和科学团体的抗议，在政府和参议员中想尽办法为烟草业谋取最大利 益。
　　尼克还有两个知心朋友――为酒业代言的波利（玛丽亚•贝罗 Maria Bello 饰）和为军火业代言的鲍比（大卫•科恩查内 David Koechner 饰）。相同的行业性质让三人成为无话不谈的密友，经常在一起交流怎样对付环保团体等各种社团的抗议、如何在政府、参议员中周旋的诀窍。
　　在政治和商业互相交错的舞台上，他们上演了一出又一出好戏。

　　Maca (María Valverde), 30 years old and clumsy by nature, makes the most of life and strives to be happy. Maca's talent is wasted working as an assistant for an oppressive and terrifying fashion influencer and she spends her time with guys with whom she never manages to establish an emotional bond. Together with Jimena (Elísabet Casanovas) and Adriana (Susana Abaitúa), her two unique and lovable friends who are always ready to do whatever it takes to make their problems not seem so bad, Maca has managed to make Madrid a city where everything is possible. Everything seems to be going well until he-who-must-not-be-named comes back into her life. Leo (Alex González), the love and biggest mistake of her life, the man who tore her heart apart, obliterated her self-esteem and her faith in men, comes back into her life to turn everything upside down. Maca has tried to forget him, but now she has to accept that he has returned and face the emotions she has locked away to deal with the unforgettable memory of what could have been and never was. Old wounds are reopened and Maca will have to be brave and confront her conflicts, fears and insecurities in order to finally take control of her life.